SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD), Tag-free bundle This mutation (Y453F) is located

This mutation (Y453F) is located in a conservative region of the RBD directly involved in ACE2 binding and thereby could have implications for viral fitness

RefSeq Links: HGNC:11766

This interaction serves as negative feedback mechanism to modulate T cell activation and to prevent excessive immune responses

The Y453F mutation (also called Danish Mink mutation / Cluster 5 mutation (ΔFVI-spike)) was first discovered in Denmark and is located in a conservative region of the RBD directly involved in ACE2 binding

hematopoiesis as well as the differentiation of naïve CD4+ T lymphocytes into IL-17 producing helper T cells

SARS-CoV-2 (COVID-19) Spike S1 Protein (RBD), Tag-free bundle This mutation (Y453F) is locatedRecombinant protein of the receptor binding domain (RBD) of SARS CoV 2 (COVID 2019) Spike S1 from Wuhan pneumonia virus, no affinity Tags or other artificial sequences present. Preclinical Version available on request: includes additional QC and more data Overview Product Name: SARS CoV 2 (COVID 19) Spike S1 Protein (RBD), Tag free Catalog No.: P2020 022 RefSeq Links: NC_045512. 2; MN908947. 3; YP_009724390. 1; QHD43416. 1; GeneID: 43740568; UniProt: